Paola Forabosco

Researcher

Area of interest:

System Biology/Gene Co-expression Networks: generation and analysis of weighted gene co-expression networks from genome-wide expression data (microarray, RNAseq). Co-expression networks are based on correlations in genes expression and aim at identifying molecular signatures within the data. Clusters of highly correlated genes (consistently co-expressed, thus likely co-regulated) are identified and annotated to relevant biological pathways.

Most significant publications:

2017

Botía, Juan A; Vandrovcova, Jana; Forabosco, Paola; Guelfi, Sebastian; D'Sa, Karishma; Consortium, United Kingdom Brain Expression; Hardy, John; Lewis, Cathryn M; Ryten, Mina; Weale, Michael E

An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks Journal Article

In: BMC systems biology, 11 (1), pp. 47, 2017, ISSN: 1752-0509.

Abstract | Links | BibTeX

2016

Bettencourt, Conceição; Forabosco, Paola; Wiethoff, Sarah; Heidari, Moones; Johnstone, Daniel M; Botía, Juan A; Collingwood, Joanna F; Hardy, John; (UKBEC), UK Brain Expression Consortium; Milward, Elizabeth A; Ryten, Mina; Houlden, Henry

Gene co-expression networks shed light into diseases of brain iron accumulation Journal Article

In: Neurobiology of Disease, 87 , pp. 59–68, 2016, ISSN: 1095-953X.

Abstract | Links | BibTeX

2015

Mencacci, Niccolo E; Rubio-Agusti, Ignacio; Zdebik, Anselm; Asmus, Friedrich; Ludtmann, Marthe H R; Ryten, Mina; Plagnol, Vincent; Hauser, Ann-Kathrin; Bandres-Ciga, Sara; Bettencourt, Conceição; Forabosco, Paola; Hughes, Deborah; Soutar, Marc M P; Peall, Kathryn; Morris, Huw R; Trabzuni, Daniah; Tekman, Mehmet; Stanescu, Horia C; Kleta, Robert; Carecchio, Miryam; Zorzi, Giovanna; Nardocci, Nardo; Garavaglia, Barbara; Lohmann, Ebba; Weissbach, Anne; Klein, Christine; Hardy, John; Pittman, Alan M; Foltynie, Thomas; Abramov, Andrey Y; Gasser, Thomas; Bhatia, Kailash P; Wood, Nicholas W

A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia Journal Article

In: American Journal of Human Genetics, 96 (6), pp. 938–947, 2015, ISSN: 1537-6605.

Abstract | Links | BibTeX

2014

Cruchaga, Carlos; Karch, Celeste M; Jin, Sheng Chih; Benitez, Bruno A; Cai, Yefei; Guerreiro, Rita; Harari, Oscar; Norton, Joanne; Budde, John; Bertelsen, Sarah; Jeng, Amanda T; Cooper, Breanna; Skorupa, Tara; Carrell, David; Levitch, Denise; Hsu, Simon; Choi, Jiyoon; Ryten, Mina; Consortium, UK Brain Expression; Hardy, John; Ryten, Mina; Trabzuni, Daniah; Weale, Michael E; Ramasamy, Adaikalavan; Smith, Colin; Sassi, Celeste; Bras, Jose; Gibbs, Raphael J; Hernandez, Dena G; Lupton, Michelle K; Powell, John; Forabosco, Paola; Ridge, Perry G; Corcoran, Christopher D; Tschanz, Joann T; Norton, Maria C; Munger, Ronald G; Schmutz, Cameron; Leary, Maegan; Demirci, Yesim F; Bamne, Mikhil N; Wang, Xingbin; Lopez, Oscar L; Ganguli, Mary; Medway, Christopher; Turton, James; Lord, Jenny; Braae, Anne; Barber, Imelda; Brown, Kristelle; Consortium, Alzheimer's Research UK; Passmore, Peter; Craig, David; Johnston, Janet; McGuinness, Bernadette; Todd, Stephen; Heun, Reinhard; Kölsch, Heike; Kehoe, Patrick G; Hooper, Nigel M; Vardy, Emma R L C; Mann, David M; Pickering-Brown, Stuart; Brown, Kristelle; Kalsheker, Noor; Lowe, James; Morgan, Kevin; Smith, A David; Wilcock, Gordon; Warden, Donald; Holmes, Clive; Pastor, Pau; Lorenzo-Betancor, Oswaldo; Brkanac, Zoran; Scott, Erick; Topol, Eric; Morgan, Kevin; Rogaeva, Ekaterina; Singleton, Andrew B; Hardy, John; Kamboh, Ilyas M; George-Hyslop, Peter St; Cairns, Nigel; Morris, John C; Kauwe, John S K; Goate, Alison M

Rare coding variants in the phospholipase Đ3 gene confer risk for Alzheimer's disease Journal Article

In: Nature, 505 (7484), pp. 550–554, 2014, ISSN: 1476-4687.

Abstract | Links | BibTeX

2013

Forabosco, Paola; Ramasamy, Adaikalavan; Trabzuni, Daniah; Walker, Robert; Smith, Colin; Bras, Jose; Levine, Adam P; Hardy, John; Pocock, Jennifer M; Guerreiro, Rita; Weale, Michael E; Ryten, Mina

Insights into TREM2 biology by network analysis of human brain gene expression data Journal Article

In: Neurobiology of Aging, 34 (12), pp. 2699–2714, 2013, ISSN: 1558-1497.

Abstract | Links | BibTeX