Veronica Marrella

@article{pmid32311393,

title = {Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome},

author = {R Rigoni and E Fontana and K Dobbs and V Marrella and V Taverniti and V Maina and A Facoetti and G DÁmico and W Al-Herz and M E Cruz-Munoz and C Schuetz and A R Gennery and E K Garabedian and S Giliani and D Draper and G Dbaibo and R S Geha and I Meyts and T Tousseyn and B Neven and D Moshous and A Fischer and A Schulz and A Finocchi and D B Kuhns and D L Fink and M S Lionakis and M Swamydas and S Guglielmetti and J Alejo and I A Myles and S Pittaluga and L D Notarangelo and A Villa and B Cassani},

year  = {2020},

date = {2020-11-01},

journal = {J Allergy Clin Immunol},

volume = {146},

number = {5},

pages = {1165--1179},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid29105104,

title = {B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury},

author = {F Faggioli and E Palagano and L Di Tommaso and M Donadon and V Marrella and C Recordati and S Mantero and A Villa and P Vezzoni and B Cassani},

year  = {2018},

date = {2018-01-01},

journal = {Hepatology},

volume = {67},

number = {5},

pages = {1970--1985},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{marrella_il-10_2015,

title = {IL-10 critically modulates B cell responsiveness in Rankl-/- mice},

author = {Veronica Marrella and Nadia {Lo Iacono} and Elena Fontana and Cristina Sobacchi and Heiko Sic and Francesca Schena and Lucia Sereni and Maria Carmina Castiello and Pietro Luigi Poliani and Paolo Vezzoni and Barbara Cassani and Elisabetta Traggiai and Anna Villa},

doi = {10.4049/jimmunol.1401977},

issn = {1550-6606},

year  = {2015},

date = {2015-05-01},

journal = {Journal of Immunology (Baltimore, Md.: 1950)},

volume = {194},

number = {9},

pages = {4144--4153},

abstract = {The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context, receptor activator of NF-κB (RANK) ligand (RANKL) plays a pivotal role in lymphoid tissue formation and bone homeostasis. Although murine models lacking RANK or RANKL show defects in B cell number, the role of the RANKL-RANK axis on B physiology is still a matter of debate. In this study, we have characterized in detail B cell compartment in Rankl(-/-) mice, finding a relative expansion of marginal zone B cells, B1 cells, and plasma cells associated with increased Ig serum levels, spontaneous germinal center formation, and hyperresponse to CD40 triggering. Such abnormalities were associated with an increased frequency of regulatory B cells and augmented B cell-derived IL-10 production. Remarkably, in vivo IL-10-R blockade reduced T cell-triggered plasma cell differentiation and restrained the expansion of regulatory B cells. These data point to a novel role of the RANKL-RANK axis in the regulation of B cell homeostasis and highlight an unexpected link between IL-10 CD40 signaling and the RANKL pathway.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24052573,

title = {Ħypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration},

author = {V Maina and V Marrella and S Mantero and B Cassani and E Fontana and A Anselmo and A Del Prete and S Sozzani and P Vezzoni and P L Poliani and A Villa},

year  = {2013},

date = {2013-12-01},

journal = {J Leukoc Biol},

volume = {94},

number = {6},

pages = {1221--1230},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{lo_iacono_osteopetrosis_2012,

title = {Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO},

author = {Nadia {Lo Iacono} and Harry C Blair and Pietro L Poliani and Veronica Marrella and Francesca Ficara and Barbara Cassani and Fabio Facchetti and Elena Fontana and Matteo M Guerrini and Elisabetta Traggiai and Francesca Schena and Marianna Paulis and Stefano Mantero and Antonio Inforzato and Serenella Valaperta and Alessandra Pangrazio and Laura Crisafulli and Virginia Maina and Paul Kostenuik and Paolo Vezzoni and Anna Villa and Cristina Sobacchi},

doi = {10.1002/jbmr.1712},

issn = {1523-4681},

year  = {2012},

date = {2012-12-01},

journal = {Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research},

volume = {27},

number = {12},

pages = {2501--2510},

abstract = {In the last decades the molecular basis of monogenic diseases has been largely unraveled, although their treatment has often remained unsatisfactory. Autosomal recessive osteopetrosis (ARO) belongs to the small group of genetic diseases that are usually treated with hematopoietic stem cell transplantation (HSCT). However, this approach is not effective in the recently identified form carrying mutations in the receptor activator of NF-κB ligand (RANKL) gene. In this subset, therapy replacement approach based on RANKL delivery has a strong rationale. Here we demonstrate that the systematic administration of RANKL for 1 month to Rankl(-/-) mice, which closely resemble the human disease, significantly improves the bone phenotype and has beneficial effects on bone marrow, spleen and thymus; major adverse effects arise only when mice are clearly overtreated. Overall, we provide evidence that the pharmacological administration of RANKL represents the appropriate treatment option for RANKL-deficient ARO patients, to be validated in a pilot clinical trial.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22723555,

title = {Anti-CĐ3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications},

author = {V Marrella and P L Poliani and E Fontana and A Casati and V Maina and B Cassani and F Ficara and M Cominelli and F Schena and M Paulis and E Traggiai and P Vezzoni and F Grassi and A Villa},

year  = {2012},

date = {2012-01-01},

journal = {Blood},

volume = {120},

number = {5},

pages = {1005--1014},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid20109747,

title = {Đefect of regulatory Ŧ cells in patients with Omenn syndrome},

author = {B Cassani and P L Poliani and D Moratto and C Sobacchi and V Marrella and L Imperatori and D Vairo and A Plebani and S Giliani and P Vezzoni and F Facchetti and F Porta and L D Notarangelo and A Villa and R Badolato},

year  = {2010},

date = {2010-01-01},

journal = {J Allergy Clin Immunol},

volume = {125},

number = {1},

pages = {209--216},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid17476358,

title = {A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome},

author = {V Marrella and P L Poliani and A Casati and F Rucci and L Frascoli and M L Gougeon and B Lemercier and M Bosticardo and M Ravanini and M Battaglia and M G Roncarolo and M Cavazzana-Calvo and F Facchetti and L D Notarangelo and P Vezzoni and F Grassi and A Villa},

year  = {2007},

date = {2007-05-01},

journal = {J Clin Invest},

volume = {117},

number = {5},

pages = {1260--1269},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid15837556,

title = {C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation},

author = {C Storini and E Rossi and V Marrella and M Distaso and R Veerhuis and C Vergani and L Bergamaschini and M G De Simoni},

year  = {2005},

date = {2005-01-01},

journal = {Neurobiol Dis},

volume = {19},

number = {1-2},

pages = {10--17},

keywords = {},

pubstate = {published},

tppubtype = {article}

}