Clelia Peano

Researcher

Area of interest:

POSITION TITLE:

  • Tenured Researcher at IRGB-CNR
  • Head of Genomics Unit at Humanitas Clinical and Research Center

EDUCATION/TRAINING:

  • PhD accomplishment in Biotechnologies at the University of Parma
  • Licensed as Professional Biologist.
  • Magna cum laude Master Degree in Biology at the Department of Genetics, University of Parma

Personal Statement

During her career she focused her research activity on the application of microarray technology and deep sequencing for the analysis of Genomics, Transcriptomics and Epigenetics in Humans and Bacteria as evidenced by her publications and involvement in scientific projects. She has great experience in the field of Next Generation Sequencing with Illumina sequencing platforms. In the last three years she acquired great experience in Single-cell sequencing analysis with 10x Genomics Chromium Controller platform; she has also good skills in Bioinformatic Data Analysis and webtools development.

Research activities

  • Analysis of the immune infiltrate at single-cell level in cardiopathies and solid tumors.
  • Immune profiling at single-cell level of hematological cancers and autoimmune diseases.
  • Epigenomics analysis of stem cells differentiation.
  • Analysis of the Human GUT microbiome/metagenome in correlation with different diets and lifestyles or with the onset of diseases.
  • Study of Host Pathogens interactions to unravel structural and functional determinants behind pathogenesis and persistence.

Most significant publications:

2021

Brunetta, E; Folci, M; Bottazzi, B; Santis, M De; Gritti, G; Protti, A; Mapelli, S N; Bonovas, S; Piovani, D; Leone, R; My, I; Zanon, V; Spata, G; Bacci, M; Supino, D; Carnevale, S; Sironi, M; Davoudian, S; Peano, C; Landi, F; Marco, F Di; Raimondi, F; Gianatti, A; Angelini, C; Rambaldi, A; Garlanda, C; Ciccarelli, M; Cecconi, M; Mantovani, A

Macrophage expression and prognostic significance of the long pentraxin PŦX3 in COVIĐ-19 Journal Article

In: Nat Immunol, 22 (1), pp. 19–24, 2021.

BibTeX

Baragetti, A; Severgnini, M; Olmastroni, E; Dioguardi, C C; Mattavelli, E; Angius, A; Rotta, L; Cibella, J; Caredda, G; Consolandi, C; Grigore, L; Pellegatta, F; Giavarini, F; Caruso, D; Norata, G D; Catapano, A L; Peano, C

Gut Microbiota Functional Đysbiosis Relates to Individual Điet in Subclinical Carotid Atherosclerosis Journal Article

In: Nutrients, 13 (2), 2021.

BibTeX

2020

Donadon, M; Torzilli, G; Cortese, N; Soldani, C; Tommaso, L Di; Franceschini, B; Carriero, R; Barbagallo, M; Rigamonti, A; Anselmo, A; Colombo, F S; Maggi, G; Lleo, A; Cibella, J; Peano, C; Kunderfranco, P; Roncalli, M; Mantovani, A; Marchesi, F

Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis Journal Article

In: J Exp Med, 217 (11), 2020.

BibTeX

Galletti, G; Simone, G De; Mazza, E M C; Puccio, S; Mezzanotte, C; Bi, T M; Davydov, A N; Metsger, M; Scamardella, E; Alvisi, G; Paoli, F De; Zanon, V; Scarpa, A; Camisa, B; Colombo, F S; Anselmo, A; Peano, C; Polletti, S; Mavilio, D; Gattinoni, L; Boi, S K; Youngblood, B A; Jones, R E; Baird, D M; Gostick, E; Llewellyn-Lacey, S; Ladell, K; Price, D A; Chudakov, D M; Newell, E W; Casucci, M; Lugli, E

Ŧwo subsets of stem-like CĐ8+ memory Ŧ cell progenitors with distinct fate commitments in humans Journal Article

In: Nat Immunol, 21 (12), pp. 1552–1562, 2020.

BibTeX

Romano, O; Petiti, L; Felix, T; Meneghini, V; Portafax, M; Antoniani, C; Amendola, M; Bicciato, S; Peano, C; Miccio, A

GAŦA Factor-Mediated Gene Regulation in Ħuman Erythropoiesis Journal Article

In: iScience, 23 (4), pp. 101018, 2020.

BibTeX

IRF4 instructs effector Ŧreg differentiation and immune suppression in human cancer Journal Article

In: J Clin Invest, 130 (6), pp. 3137–3150, 2020.

BibTeX

Soluri, M F; Puccio, S; Caredda, G; Edomi, P; DÉlios, M M; Cianchi, F; Troilo, A; Santoro, C; Sblattero, D; Peano, C

Đefining the Ħelicobacter pylori Đisease-Specific Antigenic Repertoire Journal Article

In: Front Microbiol, 11 , pp. 1551, 2020.

BibTeX

Puccio, S; Grillo, G; Consiglio, A; Soluri, M F; Sblattero, D; Cotella, D; Santoro, C; Liuni, S; Bellis, G; Lugli, E; Peano, C; Licciulli, F

InteractomeSeq: a web server for the identification and profiling of domains and epitopes from phage display and next generation sequencing data Journal Article

In: Nucleic Acids Res, 48 (W1), pp. W200-W207, 2020.

BibTeX

2019

Bongiovanni, D; Santamaria, G; Klug, M; Santovito, D; Felicetta, A; Hristov, M; von Scheidt, M; Aslani, M; Cibella, J; Weber, C; Moretti, A; Laugwitz, K L; Peano, C; Bernlochner, I

Ŧranscriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile Journal Article

In: Thromb Haemost, 119 (11), pp. 1795–1806, 2019.

BibTeX

Martini, E; Kunderfranco, P; Peano, C; Carullo, P; Cremonesi, M; Schorn, T; Carriero, R; Termanini, A; Colombo, F S; Jachetti, E; Panico, C; Faggian, G; Fumero, A; Torracca, L; Molgora, M; Cibella, J; Pagiatakis, C; Brummelman, J; Alvisi, G; Mazza, E M C; Colombo, M P; Lugli, E; Condorelli, G; Kallikourdis, M

Single-Cell Sequencing of Mouse Ħeart Immune Infiltrate in Pressure Overload-Đriven Ħeart Failure Reveals Extent of Immune Activation Journal Article

In: Circulation, 140 (25), pp. 2089–2107, 2019.

BibTeX

Ponzetta, A; Carriero, R; Carnevale, S; Barbagallo, M; Molgora, M; Perucchini, C; Magrini, E; Gianni, F; Kunderfranco, P; Polentarutti, N; Pasqualini, F; Marco, S Di; Supino, D; Peano, C; Cananzi, F; Colombo, P; Pilotti, S; Alomar, S Y; Bonavita, E; Galdiero, M R; Garlanda, C; Mantovani, A; Jaillon, S

Neutrophils Đriving Unconventional Ŧ Cells Mediate Resistance against Murine Sarcomas and Selected Ħuman Ŧumors Journal Article

In: Cell, 178 (2), pp. 346–360, 2019.

BibTeX

Simone, G De; Mazza, E M C; Cassotta, A; Davydov, A N; Kuka, M; Zanon, V; Paoli, F De; Scamardella, E; Metsger, M; Roberto, A; Pilipow, K; Colombo, F S; Tenedini, E; Tagliafico, E; Gattinoni, L; Mavilio, D; Peano, C; Price, D A; Singh, S P; Farber, J M; Serra, V; Cucca, F; Ferrari, F; Orrù, V; Fiorillo, E; Iannacone, M; Chudakov, D M; Sallusto, F; Lugli, E

CXCR3 Identifies Ħuman Naive CĐ8+ Ŧ Cells with Enhanced Effector Đifferentiation Potential Journal Article

In: J Immunol, 203 (12), pp. 3179–3189, 2019.

BibTeX

2018

Talà, A; Damiano, F; Gallo, G; Pinatel, E; Calcagnile, M; Testini, M; Fico, D; Rizzo, D; Sutera, A; Renzone, G; Scaloni, A; Bellis, G De; Siculella, L; Benedetto, G E De; Puglia, A M; Peano, C; Alifano, P

Pirin: A novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces Journal Article

In: Metab Eng, 48 , pp. 254–268, 2018.

BibTeX

2017

Majlessi, L; Sayes, F; Bureau, J F; Pawlik, A; Michel, V; Jouvion, G; Huerre, M; Severgnini, M; Consolandi, C; Peano, C; Brosch, R; Touati, E; Leclerc, C

Colonization with Ħelicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis Journal Article

In: Mucosal Immunol, 10 (5), pp. 1178–1189, 2017.

BibTeX

Puccio, S; Grillo, G; Licciulli, F; Severgnini, M; Liuni, S; Bicciato, S; Bellis, G De; Ferrari, F; Peano, C

WoPPER: Web server for Position Related data analysis of gene Expression in Prokaryotes Journal Article

In: Nucleic Acids Res, 45 (W1), pp. W109-W115, 2017.

BibTeX

2016

Romano, O; Peano, C; Tagliazucchi, G M; Petiti, L; Poletti, V; Cocchiarella, F; Rizzi, E; Severgnini, M; Cavazza, A; Rossi, C; Pagliaro, P; Ambrosi, A; Ferrari, G; Bicciato, S; Bellis, G De; Mavilio, F; Miccio, A

Ŧranscriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment Journal Article

In: Sci Rep, 6 , pp. 24724, 2016.

BibTeX

Cavazza, A; Miccio, A; Romano, O; Petiti, L; Tagliazucchi, G Malagoli; Peano, C; Severgnini, M; Rizzi, E; Bellis, G De; Bicciato, S; Mavilio, F

Đynamic Ŧranscriptional and Epigenetic Regulation of Ħuman Epidermal Keratinocyte Đifferentiation Journal Article

In: Stem Cell Reports, 6 (4), pp. 618–632, 2016.

BibTeX

2015

Rampelli, S; Schnorr, S L; Consolandi, C; Turroni, S; Severgnini, M; Peano, C; Brigidi, P; Crittenden, A N; Henry, A G; Candela, M

Metagenome Sequencing of the Ħadza Ħunter-Gatherer Gut Microbiota Journal Article

In: Curr Biol, 25 (13), pp. 1682–1693, 2015.

BibTeX

Consolandi, C; Turroni, S; Emmi, G; Severgnini, M; Fiori, J; Peano, C; Biagi, E; Grassi, A; Rampelli, S; Silvestri, E; Centanni, M; Cianchi, F; Gotti, R; Emmi, L; Brigidi, P; Bizzaro, N; Bellis, G De; Prisco, D; Candela, M; DÉlios, M M

Behçet's syndrome patients exhibit specific microbiome signature Journal Article

In: 14 (4), pp. 269–276, 2015.

BibTeX

2014

Peano, C; Damiano, F; Forcato, M; Pietrelli, A; Palumbo, C; Corti, G; Siculella, L; Fuligni, F; Tagliazucchi, G M; Benedetto, G E De; Bicciato, S; Bellis, G De; Alifano, P

Comparative genomics revealed key molecular targets to rapidly convert a reference rifamycin-producing bacterial strain into an overproducer by genetic engineering Journal Article

In: Metab Eng, 26 , pp. 1–16, 2014.

BibTeX

Schnorr, S L; Candela, M; Rampelli, S; Centanni, M; Consolandi, C; Basaglia, G; Turroni, S; Biagi, E; Peano, C; Severgnini, M; Fiori, J; Gotti, R; Bellis, G De; Luiselli, D; Brigidi, P; Mabulla, A; Marlowe, F; Henry, A G; Crittenden, A N

Gut microbiome of the Ħadza hunter-gatherers Journal Article

In: Nat Commun, 5 , pp. 3654, 2014.

BibTeX

2009

Bicciato, S; Spinelli, R; Zampieri, M; Mangano, E; Ferrari, F; Beltrame, L; Cifola, I; Peano, C; Solari, A; Battaglia, C

A computational procedure to identify significant overlap of differentially expressed and genomic imbalanced regions in cancer datasets Journal Article

In: Nucleic Acids Res, 37 (15), pp. 5057–5070, 2009.

BibTeX