Michele Marongiu

Technician

Area of interest:

Michele Marongiu is a Bioinformatician and Data Scientist at CNR-IRGB (Lanusei). He specializes in the computational and statistical analysis of complex biomedical data, with a specific focus on genomics, clinical phenotypes, and multi-omics integration within population-based cohorts and translational studies.

His expertise spans the entire data lifecycle: from the acquisition, harmonization, and quality control (QC) of heterogeneous datasets to the implementation of reproducible and scalable pipelines in Linux/HPC environments. He also focuses on developing detailed reports and reusable resources to support large-scale research activities.

His primary research areas include population and statistical genetics, particularly:

  • Genome-Wide Association Studies (GWAS): defining and interpreting signals and loci.
  • Biological Integration: combining statistical evidence to interpret complex biological results.

Additionally, he employs Artificial Intelligence—specifically Machine Learning and Deep Learning—for predictive modeling and the identification of informative patterns in high-dimensional, multi-source data (genetic, clinical, and multi-omics).

Currently, he is a PhD student at the University of Sassari, where his research project focuses on the “Role of Intestinal Mucosal Immunity and the Microbiota in the Pathogenesis of Autoimmune Diseases.”

Michele has co-authored 37 peer-reviewed articles indexed in PubMed. An up-to-date list of his publications and persistent identifiers can be found via ORCID and PubMed.

Most significant publications:

  • Marongiu M, Pérez-Mejías G, Orrù V, et al. GWAS of genetic factors affecting white blood cell morphological parameters in Sardinians uncovers influence of chromosome 11 innate immunity gene cluster on eosinophil morphology. Hum Mol Genet. 2023 Feb 19;32(5):790-797. doi: 10.1093/hmg/ddac238. PMID: 36136759.
  • Orrù V, Steri M, Sidore C, Marongiu M, et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet. 2020 Oct;52(10):1036-1045. doi: 10.1038/s41588-020-0684-4. PMID: 32929287.
  • Steri M, Orrù V, et al. Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017 Apr 27;376(17):1615-1626. doi: 10.1056/NEJMoa1610528. PMID: 28445677.
  • Orrù V, Steri M, Sole G, Sidore C, et al. Genetic variants regulating immune cell levels in health and disease. Cell. 2013 Sep 26;155(1):242-256. doi: 10.1016/j.cell.2013.08.041. PMID: 24074872.
  • Fabre MA, de Almeida JG, Fiorillo E, et al. The longitudinal dynamics and natural history of clonal haematopoiesis. Nature. 2022 Jun;606(7913):335-342. doi: 10.1038/s41586-022-04785-z. PMID: 35650444.
  • Zoledziewska M, Sidore C, Chiang CWK, et al. Height-reducing variants and selection for short stature in Sardinia. Nat Genet. 2015 Nov;47(11):1352-1356. doi: 10.1038/ng.3403. PMID: 26366551.
  • Olivieri A, Sidore C, Achilli A, et al. Mitogenome Diversity in Sardinians: A Genetic Window onto an Island’s Past. Mol Biol Evol. 2017 May 1;34(5):1230-1239. doi: 10.1093/molbev/msx082. PMID: 28177087.

Link: