Serena Sanna

@article{pmid35115690,

title = {Effect of host genetics on the gut microbiome in 7,738 participants of the Đutch Microbiome Project},

author = {E. A. Lopera-Maya and A. Kurilshikov and A. Graaf and S. Hu and S. Andreu-Sánchez and L. Chen and A. V. Vila and R. Gacesa and T. Sinha and V. Collij and M. A. Y. Klaassen and L. A. Bolte and M. F. B. Gois and P. B. T. Neerincx and M. A. Swertz and H. J. M. Harmsen and C. Wijmenga and J. Fu and R. K. Weersma and A. Zhernakova and S. Sanna and R. Aguirre-Gamboa and P. Deelen and L. Franke and J. A. Kuivenhoven and E. A. Lopera-Maya and I. M. Nolte and S. Sanna and H. Snieder and M. A. Swertz and J. M. Vonk and C. Wijmenga},

url = {https://www.nature.com/articles/s41588-021-00992-y},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Nat Genet},

volume = {54},

number = {2},

pages = {143--151},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35115688b,

title = {Challenges and future directions for studying effects of host genetics on the gut microbiome},

author = {S. Sanna and A. Kurilshikov and A. Graaf and J. Fu and A. Zhernakova},

url = {https://www.nature.com/articles/s41588-021-00983-z},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Nat Genet},

volume = {54},

number = {2},

pages = {100--106},

abstract = {1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome.},

note = {[DOI:hrefhttps://dx.doi.org/10.1038/s41588-021-00983-z10.1038/s41588-021-00983-z] [PubMed:hrefhttps://www.ncbi.nlm.nih.gov/pubmed/3278393532783935]},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33004804,

title = {Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids},

author = {A van der Graaf and A Claringbould and A Rimbert and H J Westra and Y Li and C Wijmenga and S Sanna and B T Heijmans and P A C ' Hoen and J B J van Meurs and R Jansen and L Franke},

year  = {2020},

date = {2020-01-01},

journal = {Nat Commun},

volume = {11},

number = {1},

pages = {4930},

abstract = {Inference of causality between gene expression and complex traits using Mendelian randomization (MR) is confounded by pleiotropy and linkage disequilibrium (LD) of gene-expression quantitative trait loci (eQTL). Here, we propose an MR method, MR-link, that accounts for unobserved pleiotropy and LD by leveraging information from individual-level data, even when only one eQTL variant is present. In simulations, MR-link shows false-positive rates close to expectation (median 0.05) and high power (up to 0.89), outperforming all other tested MR methods and coloc. Application of MR-link to low-density lipoprotein cholesterol (LDL-C) measurements in 12,449 individuals with expression and protein QTL summary statistics from blood and liver identifies 25 genes causally linked to LDL-C. These include the known SORT1 and ApoE genes as well as PVRL2, located in the APOE locus, for which a causal role in liver was not known. Our results showcase the strength of MR-link for transcriptome-wide causal inferences.},

note = {[PubMed Central:hrefhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530717PMC7530717] [DOI:hrefhttps://dx.doi.org/10.1038/s41467-020-18716-x10.1038/s41467-020-18716-x] [PubMed:hrefhttps://www.ncbi.nlm.nih.gov/pubmed/2346866323468663]},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sanna2019,

title = {Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases},

author = {Serena Sanna and Natalie R van Zuydam and Anubha Mahajan and Alexander Kurilshikov and Arnau Vich Vila and Urmo V õ and Zlatan Mujagic and Ad A M Masclee and Daisy M A E Jonkers and Marije Oosting and Leo A B Joosten and Mihai G Netea and Lude Franke and Alexandra Zhernakova and Jingyuan Fu and Cisca Wijmenga and Mark I McCarthy},

url = {https://doi.org/10.1038/s41588-019-0350-x},

doi = {10.1038/s41588-019-0350-x},

year  = {2019},

date = {2019-01-01},

journal = {Nature Genetics},

volume = {51},

number = {4},

pages = {600--605},

publisher = {Springer Nature},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Danjou2015,

title = {Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels},

author = {Fabrice Danjou and Magdalena Zoledziewska and Carlo Sidore and Maristella Steri and Fabio Busonero and Andrea Maschio and Antonella Mulas and Lucia Perseu and Susanna Barella and Eleonora Porcu and Giorgio Pistis and Maristella Pitzalis and Mauro Pala and Stephan Menzel and Sarah Metrustry and Timothy D Spector and Lidia Leoni and Andrea Angius and Manuela Uda and Paolo Moi and Swee Lay Thein and Renzo Galanello and Gon ç and David Schlessinger and Serena Sanna and Francesco Cucca},

url = {https://doi.org/10.1038/ng.3307},

doi = {10.1038/ng.3307},

year  = {2015},

date = {2015-01-01},

journal = {Nature Genetics},

volume = {47},

number = {11},

pages = {1264--1271},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sidore2015,

title = {Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers},

author = {Carlo Sidore and Fabio Busonero and Andrea Maschio and Eleonora Porcu and Silvia Naitza and Magdalena Zoledziewska and Antonella Mulas and Giorgio Pistis and Maristella Steri and Fabrice Danjou and Alan Kwong and Vicente Diego Ortega del Vecchyo and Charleston W K Chiang and Jennifer Bragg-Gresham and Maristella Pitzalis and Ramaiah Nagaraja and Brendan Tarrier and Christine Brennan and Sergio Uzzau and Christian Fuchsberger and Rossano Atzeni and Frederic Reinier and Riccardo Berutti and Jie Huang and Nicholas J Timpson and Daniela Toniolo and Paolo Gasparini and Giovanni Malerba and George Dedoussis and Eleftheria Zeggini and Nicole Soranzo and Chris Jones and Robert Lyons and Andrea Angius and Hyun M Kang and John Novembre and Serena Sanna and David Schlessinger and Francesco Cucca and Gon ç},

url = {https://doi.org/10.1038/ng.3368},

doi = {10.1038/ng.3368},

year  = {2015},

date = {2015-01-01},

journal = {Nature Genetics},

volume = {47},

number = {11},

pages = {1272--1281},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pistis2014,

title = {Rare variant genotype imputation with thousands of study-specific whole-genome sequences: implications for cost-effective study designs},

author = {Giorgio Pistis and Eleonora Porcu and Scott I Vrieze and Carlo Sidore and Maristella Steri and Fabrice Danjou and Fabio Busonero and Antonella Mulas and Magdalena Zoledziewska and Andrea Maschio and Christine Brennan and Sandra Lai and Michael B Miller and Marco Marcelli and Maria Francesca Urru and Maristella Pitzalis and Robert H Lyons and Hyun M Kang and Chris M Jones and Andrea Angius and William G Iacono and David Schlessinger and Matt McGue and Francesco Cucca and Gon ç and Serena Sanna},

url = {https://doi.org/10.1038/ejhg.2014.216},

doi = {10.1038/ejhg.2014.216},

year  = {2014},

date = {2014-01-01},

journal = {European Journal of Human Genetics},

volume = {23},

number = {7},

pages = {975--983},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sanna2011,

title = {Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability},

author = {Serena Sanna and Bingshan Li and Antonella Mulas and Carlo Sidore and Hyun M Kang and Anne U Jackson and Maria Grazia Piras and Gianluca Usala and Giuseppe Maninchedda and Alessandro Sassu and Fabrizio Serra and Maria Antonietta Palmas and William H Wood and Inger Nj ø and Markku Laakso and Kristian Hveem and Jaakko Tuomilehto and Timo A Lakka and Rainer Rauramaa and Michael Boehnke and Francesco Cucca and Manuela Uda and David Schlessinger and Ramaiah Nagaraja and Gon ç},

editor = {Greg Gibson},

url = {https://doi.org/10.1371/journal.pgen.1002198},

doi = {10.1371/journal.pgen.1002198},

year  = {2011},

date = {2011-01-01},

journal = {PLoS Genetics},

volume = {7},

number = {7},

pages = {e1002198},

publisher = {Public Library of Science (PLoS)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}