Daniele Catalucci

Head of Research

Area of interest:

Dr. Daniele Catalucci graduated from the University of Rome − Roma Tre, in 1999 and received his PhD in molecular and cellular biology from the University of Rome − Tor Vergata, in 2003. Supported by a Marie Curie Outgoing International Fellowship, he performed his postdoctoral studies at the Department of Medicine, University of California San Diego, USA. By the end of 2007, Dr. Catalucci moved back to Italy (Milan) where he started up his own group at the Institute of Biomedical Technologies of the National Research Council (ITB-CNR) in collaboration with the IRCCS Multimedica Hospital. In 2009, he became a tenured scientist at the Institute of Genetic and Biomedical Research (IRGB) of CNR and in 2012, his laboratory moved to the Humanitas Research Hospital.

His lab aims to dissect the molecular mechanisms underlying cardiac diseases, to increase the knowledge about the function of the physiologic vs pathologic heart, and to develop novel and more effective therapeutic approaches for the treatment of the failing heart.

Macro areas of interest: 1) Molecular mechanisms for the regulation of cardiac muscle contraction: remodeling of calcium handling, signal transduction, and identification of new therapeutic drugs. 2) Biomimetic nanoparticle formulations for cardiac-specific drug delivery, an unconventional and novel effective strategy for non-invasive (via inhalation) nanoparticle-based delivery of therapeutic biomolecules to the diseased heart.

Most significant publications:


Mauro, V Di; Ceriotti, P; Lodola, F; Salvarani, N; Modica, J; Bang, M L; Mazzanti, A; Napolitano, C; Priori, S G; Catalucci, D

Peptide-Based Ŧargeting of the L-Ŧype Calcium Channel Corrects the Loss-of-Function Phenotype of Ŧwo Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome Journal Article

In: Front Physiol, 11 , pp. 616819, 2020.



Prondzynski, M; Lemoine, M D; Zech, A T; Horváth, A; Mauro, V Di; Koivumäki, J T; Kresin, N; Busch, J; Krause, T; Krämer, E; Schlossarek, S; Spohn, M; Friedrich, F W; Münch, J; Laufer, S D; Redwood, C; Volk, A E; Hansen, A; Mearini, G; Catalucci, D; Meyer, C; Christ, T; Patten, M; Eschenhagen, T; Carrier, L

Đisease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy Journal Article

In: EMBO Mol Med, 11 (12), pp. e11115, 2019.


Mauro, V Di; Crasto, S; Colombo, F S; Pasquale, E Di; Catalucci, D

Wnt signalling mediates miR-133a nuclear re-localization for the transcriptional control of Đnmt3b in cardiac cells Journal Article

In: Sci Rep, 9 (1), pp. 9320, 2019.



Miragoli, M; Ceriotti, P; Iafisco, M; Vacchiano, M; Salvarani, N; Alogna, A; Carullo, P; Ramirez-Rodríguez, G B; Patrício, T; Esposti, L D; Rossi, F; Ravanetti, F; Pinelli, S; Alinovi, R; Erreni, M; Rossi, S; Condorelli, G; Post, H; Tampieri, A; Catalucci, D

Inhalation of peptide-loaded nanoparticles improves heart failure Journal Article

In: Sci Transl Med, 10 (424), 2018.


Romanelli, A; Affinito, A; Avitabile, C; Catuogno, S; Ceriotti, P; Iaboni, M; Modica, J; Condorelli, G; Catalucci, D

An anti-PĐGFRβ aptamer for selective delivery of small therapeutic peptide to cardiac cells Journal Article

In: PLoS One, 13 (3), pp. e0193392, 2018.


Marrella, A; Iafisco, M; Adamiano, A; Rossi, S; Aiello, M; Barandalla-Sobrados, M; Carullo, P; Miragoli, M; Tampieri, A; Scaglione, S; Catalucci, D

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases Journal Article

In: J R Soc Interface, 15 (144), 2018.



Kallikourdis, Marinos; Martini, Elisa; Carullo, Pierluigi; Sardi, Claudia; Roselli, Giuliana; Greco, Carolina M; Vignali, Debora; Riva, Federica; Berre, Anne Marie Ormbostad; Stølen, Tomas O; Fumero, Andrea; Faggian, Giuseppe; Pasquale, Elisa Di; Elia, Leonardo; Rumio, Cristiano; Catalucci, Daniele; Papait, Roberto; Condorelli, Gianluigi

T cell costimulation blockade blunts pressure overload-induced heart failure Journal Article

In: Nature Communications, 8 , pp. 14680, 2017, ISSN: 2041-1723.

Abstract | Links | BibTeX

Zaglia, T; Ceriotti, P; Campo, A; Borile, G; Armani, A; Carullo, P; Prando, V; Coppini, R; Vida, V; Stølen, T O; Ulrik, W; Cerbai, E; Stellin, G; Faggian, G; Stefani, D De; Sandri, M; Rizzuto, R; Lisa, F Di; Pozzan, T; Catalucci, D; Mongillo, M

Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy Journal Article

In: Proc Natl Acad Sci U S A, 114 (43), pp. E9006-E9015, 2017.



Rusconi, Francesca; Ceriotti, Paola; Miragoli, Michele; Carullo, Pierluigi; Salvarani, Nicolò; Rocchetti, Marcella; Pasquale, Elisa Di; Rossi, Stefano; Tessari, Maddalena; Caprari, Silvia; Cazade, Magali; Kunderfranco, Paolo; Chemin, Jean; Bang, Marie-Louise; Polticelli, Fabio; Zaza, Antonio; Faggian, Giuseppe; Condorelli, Gianluigi; Catalucci, Daniele

Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function Journal Article

In: Circulation, 134 (7), pp. 534–546, 2016, ISSN: 1524-4539.

Abstract | Links | BibTeX

Mauro, Vittoria Di; Iafisco, Michele; Salvarani, Nicolò; Vacchiano, Marco; Carullo, Pierluigi; Ramírez-Rodríguez, Gloria Belén; Patrício, Tatiana; Tampieri, Anna; Miragoli, Michele; Catalucci, Daniele

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs Journal Article

In: Nanomedicine (London, England), 11 (8), pp. 891–906, 2016, ISSN: 1748-6963.

Abstract | Links | BibTeX


Zenaro, E; Pietronigro, E; Bianca, V Della; Piacentino, G; Marongiu, L; Budui, S; Turano, E; Rossi, B; Angiari, S; Dusi, S; Montresor, A; Carlucci, T; Nanì, S; Tosadori, G; Calciano, L; Catalucci, D; Berton, G; Bonetti, B; Constantin, G

Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin Journal Article

In: Nat Med, 21 (8), pp. 880–886, 2015.



Castaldi, Alessandra; Zaglia, Tania; Mauro, Vittoria Di; Carullo, Pierluigi; Viggiani, Giacomo; Borile, Giulia; Stefano, Barbara Di; Schiattarella, Gabriele Giacomo; Gualazzi, Maria Giovanna; Elia, Leonardo; Stirparo, Giuliano Giuseppe; Colorito, Maria Luisa; Pironti, Gianluigi; Kunderfranco, Paolo; Esposito, Giovanni; Bang, Marie-Louise; Mongillo, Marco; Condorelli, Gianluigi; Catalucci, Daniele

MicroRNA-133 modulates the β1-adrenergic receptor transduction cascade Journal Article

In: Circulation Research, 115 (2), pp. 273–283, 2014, ISSN: 1524-4571.

Abstract | Links | BibTeX

Zaglia, Tania; Milan, Giulia; Ruhs, Aaron; Franzoso, Mauro; Bertaggia, Enrico; Pianca, Nicola; Carpi, Andrea; Carullo, Pierluigi; Pesce, Paola; Sacerdoti, David; Sarais, Cristiano; Catalucci, Daniele; Krüger, Marcus; Mongillo, Marco; Sandri, Marco

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy Journal Article

In: The Journal of Clinical Investigation, 124 (6), pp. 2410–2424, 2014, ISSN: 1558-8238.

Abstract | Links | BibTeX


Tritsch, E; Mallat, Y; Lefebvre, F; Diguet, N; Escoubet, B; Blanc, J; Windt, L J De; Catalucci, D; Vandecasteele, G; Li, Z; Mericskay, M

An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart Journal Article

In: Cardiovasc Res, 98 (3), pp. 372–380, 2013.


Varrone, Francesca; Gargano, Barbara; Carullo, Pierluigi; Silvestre, Dario Di; Palma, Antonella De; Grasso, Ludovica; Somma, Carolina Di; Mauri, Pierluigi; Benazzi, Louise; Franzone, Anna; Jotti, Gloria Saccani; Bang, Marie-Louise; Esposito, Giovanni; Colao, Annamaria; Condorelli, Gianluigi; Catalucci, Daniele

The circulating level of FABP3 is an indirect biomarker of microRNA-1 Journal Article

In: Journal of the American College of Cardiology, 61 (1), pp. 88–95, 2013, ISSN: 1558-3597.

Abstract | Links | BibTeX

Curcio, A; Torella, D; Iaconetti, C; Pasceri, E; Sabatino, J; Sorrentino, S; Giampà, S; Micieli, M; Polimeni, A; Henning, B J; Leone, A; Catalucci, D; Ellison, G M; Condorelli, G; Indolfi, C

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts Journal Article

In: PLoS One, 8 (7), pp. e70158, 2013.



Drawnel, F M; Wachten, D; Molkentin, J D; Maillet, M; Aronsen, J M; Swift, F; Sjaastad, I; Liu, N; Catalucci, D; Mikoshiba, K; Hisatsune, C; Okkenhaug, H; Andrews, S R; Bootman, M D; Roderick, H L

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy Journal Article

In: J Cell Biol, 199 (5), pp. 783–798, 2012.


Castoldi, G; Gioia, C R Di; Bombardi, C; Catalucci, D; Corradi, B; Gualazzi, M G; Leopizzi, M; Mancini, M; Zerbini, G; Condorelli, G; Stella, A

MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension Journal Article

In: J Cell Physiol, 227 (2), pp. 850–856, 2012.


Scimia, M C; Hurtado, C; Ray, S; Metzler, S; Wei, K; Wang, J; Woods, C E; Purcell, N H; Catalucci, D; Akasaka, T; Bueno, O F; Vlasuk, G P; Kaliman, P; Bodmer, R; Smith, L H; Ashley, E; Mercola, M; Brown, J H; Ruiz-Lozano, P

APJ acts as a dual receptor in cardiac hypertrophy Journal Article

In: Nature, 488 (7411), pp. 394–398, 2012.



Torella, D; Iaconetti, C; Catalucci, D; Ellison, G M; Leone, A; Waring, C D; Bochicchio, A; Vicinanza, C; Aquila, I; Curcio, A; Condorelli, G; Indolfi, C

MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo Journal Article

In: Circ Res, 109 (8), pp. 880–893, 2011.


Comunian, C; Rusconi, F; Palma, A De; Brunetti, P; Catalucci, D; Mauri, P L

A comparative MudPIŦ analysis identifies different expression profiles in heart compartments Journal Article

In: Proteomics, 11 (11), pp. 2320–2328, 2011.



Zhang, D; Contu, R; Latronico, M V; Zhang, J; Zhang, J L; Rizzi, R; Catalucci, D; Miyamoto, S; Huang, K; Ceci, M; Gu, Y; Dalton, N D; Peterson, K L; Guan, K L; Brown, J H; Chen, J; Sonenberg, N; Condorelli, G

MŦORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice Journal Article

In: J Clin Invest, 120 (8), pp. 2805–2816, 2010.