Maria Grazia Doro


Area of interest:

Maria Grazia Doro is a researcher at CNR-Institute of Genetic and Biomedical Research (IRGB). She graduated in Biological Sciences in 1993 at the University of Sassari. 

After graduation, her research activity was focused on cellular physiology, especially on cell adhesion and proliferation under altered gravity conditions by using cell cultures of neoplastic and normal fibroblastsSince 1997 she has been working at CNR. At first, at IPSOE-CNR, she was involved in the study of congenital and acquired blood pathologies by molecular analysis of T-cell receptor repertoire (TCR) in myelo and lymphoproliferative diseases, using PCR, RT-PCR and DNA sequencing techniques. Then, at IGP and IRGB-CNR, her research activity concerned: 1) the phylogeny and biodiversity study of autochthonous goat in Sardinia by sequencing and analysis of casein gene cluster and mitochondrial DNA; 2) the molecular characterization of globin genes in β-thalassemic patients of Central Vietnam and screening of thalassemia mutations by DNA sequencing and analysis of genetic polymorphisms. 

Currently she focuses her research activity on cancer genetics, particularly on the genetic and molecular pathogenesis of pancreatic cancer by Next Generation Sequencing (NGS) analyses with multigene panel, to identify novel tumor biomarkers associated with the disease. 

Most significant publications:


Sini, Maria Cristina; Doro, Maria Grazia; Frogheri, Laura; Zinellu, Angelo; Paliogiannis, Panagiotis; Porcu, Alberto; Scognamillo, Fabrizio; Delogu, Daniele; Santeufemia, Davide Adriano; Persico, Ivana; Palomba, Grazia; Maestrale, Giovanni Battista; Cossu, Antonio; Palmieri, Giuseppe

Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population Journal Article

In: J Transl Med, 22 (1), pp. 108, 2024, ISSN: 1479-5876.

Abstract | Links | BibTeX


Doro, Maria G.; Casu, Giuseppina; Frogheri, Laura; Persico, Ivana; Triet, Le Phan Minh; Hoa, Phan Thi Thuy; Hoang, Nguyen Huy; Pirastru, Monica; Mereu, Paolo; Cucca, Francesco; Masala, Bruno

Molecular Characterization of beta-Thalassemia Mutations in Central Vietnam. Journal Article

In: Hemoglobin, 41 (2), pp. 96–99, 2017, ISSN: 1532-432X 0363-0269.

Abstract | Links | BibTeX


Doro, Maria Grazia; Piras, Daniela; Leoni, Giovanni Giuseppe; Casu, Giuseppina; Vaccargiu, Simona; Parracciani, Debora; Naitana, Salvatore; Pirastu, Mario; Novelletto, Andrea

Phylogeny and patterns of diversity of goat mtDNA haplogroup A revealed by resequencing complete mitogenomes Journal Article

In: PloS One, 9 (4), pp. e95969, 2014, ISSN: 1932-6203.

Abstract | Links | BibTeX


Piras, Daniela; Doro, Maria Grazia; Casu, Giuseppina; Melis, Paola Maria; Vaccargiu, Simona; Piras, Ignazio; Parracciani, Debora; Stradoni, Roberta; Frongia, Bruno; Lai, Graziano; Sale, Salvatore; Cattari, Walter; Piras, Roberto; Querci, Ombretta; Demuro, Piergiorgio; Cui, Sandro; Atzori, Franco; Mancosu, Marco; Marchiori, Francesca; Cammelli, Rossana; Spiga, Alessandra; Loddo, Pier Paolo; Pili, Gianfranco; Boi, Roberto; Argiolas, Giuseppe; Mereu, Paolo; Leoni, Giovanni Giuseppe; Naitana, Salvatore; Pirastu, Mario; Novelletto, Andrea

Haplotype affinities resolve a major component of goat (Capra hircus) MtDNA D-loop diversity and reveal specific features of the Sardinian stock Journal Article

In: PloS One, 7 (2), pp. e30785, 2012, ISSN: 1932-6203.

Abstract | Links | BibTeX


Bonfigli, S.; Doro, M. G.; Fozza, C.; Derudas, D.; Dore, F.; Longinotti, M.

T-cell receptor repertoire in healthy Sardinian subjects Journal Article

In: Hum Immunol, 64 (7), pp. 689–695, 2003.

Abstract | BibTeX