Paola Luisa Cattaneo


Area of interest:

Over the last years Dr. Cattaneo dedicated her professional life to learning advanced concepts in fundamental domains of biomedical research – pharmacology, epigenetics, and transcriptional regulation – with special emphasis on cardiovascular biology. She conducted her research in leading institutions in Europe and US, focusing on distinct aspects of cardiovascular development and disease. After a period at the Karolinska Institute (Sweden) studying population genetics in the context of atherosclerosis, she conducted her graduate studies in Molecular Medicine at the University of Milan, under the supervision of Prof. Condorelli. As a graduate student she focused her research on the role of epigenetics in cardiac biology, successfully generating high resolution maps of histone modifications during cardiomyocyte differentiation. After graduation she moved to the laboratory of Prof. Evans, in the Department of Cardiology at the University of California San Diego, US. Research support from a Marie Curie International Outgoing Fellowship allowed her to develop projects in the field of cardiogenesis and cardiac fibrosis. Using sophisticated genetically modified mouse models for conditional gene knockout and lineage tracing, she has identified the origin of cardiac fibroblasts after myocardial infarction and defined the importance of selected transcription factors for cardiomyocyte proliferation and heart development. In 2017, after obtaining a permanent position as Researcher with the CNR, she returned to Italy to start her independent group. With the ultimate aim of developing regenerative therapies for the injured heart, Dr. Cattaneo’s research is focusing on understanding mechanisms by which transcription factors, epigenetic enzymes and regulatory elements control cardiomyocyte maturation and activation of cardiac fibroblasts. Towards this goal she combines advanced mouse models and state-of-the-art techniques for genomics, transcriptomics and imaging.

Most significant publications:


Cattaneo, P; Mukherjee, D; Spinozzi, S; Zhang, L; Larcher, V; Stallcup, W B; Kataoka, H; Chen, J; Dimmeler, S; Evans, S M; Guimarães-Camboa, N

Parallel Lineage-Ŧracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor Journal Article

In: Cell Rep, 30 (2), pp. 571–582, 2020.



Moore-Morris, T; Cattaneo, P; Guimarães-Camboa, N; Bogomolovas, J; Cedenilla, M; Banerjee, I; Ricote, M; Kisseleva, T; Zhang, L; Gu, Y; Dalton, N D; Peterson, K L; Chen, J; Pucéat, M; Evans, S M

Infarct Fibroblasts Đo Not Đerive From Bone Marrow Lineages Journal Article

In: Circ Res, 122 (4), pp. 583–590, 2018.



Guimarães-Camboa, N; Cattaneo, P; Sun, Y; Moore-Morris, T; Gu, Y; Dalton, N D; Rockenstein, E; Masliah, E; Peterson, K L; Stallcup, W B; Chen, J; Evans, S M

Pericytes of Multiple Organs Đo Not Behave as Mesenchymal Stem Cells In Vivo Journal Article

In: Cell Stem Cell, 20 (3), pp. 345–359, 2017.



Cattaneo, P; Kunderfranco, P; Greco, C; Guffanti, A; Stirparo, G G; Rusconi, F; Rizzi, R; Pasquale, E Di; Locatelli, S L; Latronico, M V; Bearzi, C; Papait, R; Condorelli, G

ĐOŦ1L-mediated Ħ3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation Journal Article

In: Cell Death Differ, 23 (4), pp. 555–564, 2016.



Guimarães-Camboa, N; Stowe, J; Aneas, I; Sakabe, N; Cattaneo, P; Henderson, L; Kilberg, M S; Johnson, R S; Chen, J; McCulloch, A D; Nobrega, M A; Evans, S M; Zambon, A C

ĦIF1α Represses Cell Stress Pathways to Allow Proliferation of Ħypoxic Fetal Cardiomyocytes Journal Article

In: Dev Cell, 33 (5), pp. 507–521, 2015.


Liang, X; Zhang, Q; Cattaneo, P; Zhuang, S; Gong, X; Spann, N J; Jiang, C; Cao, X; Zhao, X; Zhang, X; Bu, L; Wang, G; Chen, H S; Zhuang, T; Yan, J; Geng, P; Luo, L; Banerjee, I; Chen, Y; Glass, C K; Zambon, A C; Chen, J; Sun, Y; Evans, S M

Ŧranscription factor ISL1 is essential for pacemaker development and function Journal Article

In: J Clin Invest, 125 (8), pp. 3256–3268, 2015.



Papait, R; Cattaneo, P; Kunderfranco, P; Greco, C; Carullo, P; Guffanti, A; Viganò, V; Stirparo, G G; Latronico, M V; Hasenfuss, G; Chen, J; Condorelli, G

Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy Journal Article

In: Proc Natl Acad Sci U S A, 110 (50), pp. 20164–20169, 2013.



Norata, G D; Cattaneo, P; Poletti, A; Catapano, A L

Ŧhe androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta Journal Article

In: 212 (1), pp. 100–106, 2010.