Veronica Marrella


Area of interest:

I graduated in studies involving the inflammatory response in a mouse model of cerebral ischemia at the Mario Negri Institute in Milan in the group of Dr. MariaGrazia De Simoni. Then I started my work experience at CNR-ITB under the supervision of Dr. Anna Villa in the field of Primary immunodeficiencies (PIDs). I dealt with analysis of known and candidate genes in human patients gaining expertise in molecular and cellular methodologies. Then I moved to in vivo experiments characterizing the mouse model of Omenn syndrome, generated in our laboratory. After demonstrating that the model recapitulated the human disease, I explored the mechanisms of the peculiar autoimmune manifestations of this pathology. I focused my research on how thymic defect had impact on the peripheral dysregulation evaluating a possible therapeutic approach of the anti-CD3 antibody in combination with bone marrow transplantation. In 2010 I obtained a permanent position as Researcher with CNR. I continued studies about several immune aspects in Omenn mouse and in other model of diseases. Particularly I suggested a novel role of the RANKL-RANK axis in the regulation of B cell homeostasis highlighting an unexpected link between IL-10 CD40 signaling and the RANKL pathway. More recently, I participated to a study regarding the relationship between microbiota and immune responses. Finally, I collaborated in a study about the adaptive immune contribution to senescence in a model of liver fibrosis.  Thanks to the experience obtained in this last collaboration, I am responsible of a Unit in a project funded by Ministero della Salute regarding the interaction between cellular aging and immune response in human colorectal liver metastasis.

Most significant publications:


Rigoni, R; Fontana, E; Dobbs, K; Marrella, V; Taverniti, V; Maina, V; Facoetti, A; DÁmico, G; Al-Herz, W; Cruz-Munoz, M E; Schuetz, C; Gennery, A R; Garabedian, E K; Giliani, S; Draper, D; Dbaibo, G; Geha, R S; Meyts, I; Tousseyn, T; Neven, B; Moshous, D; Fischer, A; Schulz, A; Finocchi, A; Kuhns, D B; Fink, D L; Lionakis, M S; Swamydas, M; Guglielmetti, S; Alejo, J; Myles, I A; Pittaluga, S; Notarangelo, L D; Villa, A; Cassani, B

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome Journal Article

In: J Allergy Clin Immunol, 146 (5), pp. 1165–1179, 2020.



Faggioli, F; Palagano, E; Tommaso, L Di; Donadon, M; Marrella, V; Recordati, C; Mantero, S; Villa, A; Vezzoni, P; Cassani, B

B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury Journal Article

In: Hepatology, 67 (5), pp. 1970–1985, 2018.



Marrella, Veronica; Iacono, Nadia Lo; Fontana, Elena; Sobacchi, Cristina; Sic, Heiko; Schena, Francesca; Sereni, Lucia; Castiello, Maria Carmina; Poliani, Pietro Luigi; Vezzoni, Paolo; Cassani, Barbara; Traggiai, Elisabetta; Villa, Anna

IL-10 critically modulates B cell responsiveness in Rankl-/- mice Journal Article

In: Journal of Immunology (Baltimore, Md.: 1950), 194 (9), pp. 4144–4153, 2015, ISSN: 1550-6606.

Abstract | Links | BibTeX


Maina, V; Marrella, V; Mantero, S; Cassani, B; Fontana, E; Anselmo, A; Prete, A Del; Sozzani, S; Vezzoni, P; Poliani, P L; Villa, A

Ħypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration Journal Article

In: J Leukoc Biol, 94 (6), pp. 1221–1230, 2013.



Iacono, Nadia Lo; Blair, Harry C; Poliani, Pietro L; Marrella, Veronica; Ficara, Francesca; Cassani, Barbara; Facchetti, Fabio; Fontana, Elena; Guerrini, Matteo M; Traggiai, Elisabetta; Schena, Francesca; Paulis, Marianna; Mantero, Stefano; Inforzato, Antonio; Valaperta, Serenella; Pangrazio, Alessandra; Crisafulli, Laura; Maina, Virginia; Kostenuik, Paul; Vezzoni, Paolo; Villa, Anna; Sobacchi, Cristina

Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO Journal Article

In: Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 27 (12), pp. 2501–2510, 2012, ISSN: 1523-4681.

Abstract | Links | BibTeX

Marrella, V; Poliani, P L; Fontana, E; Casati, A; Maina, V; Cassani, B; Ficara, F; Cominelli, M; Schena, F; Paulis, M; Traggiai, E; Vezzoni, P; Grassi, F; Villa, A

Anti-CĐ3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications Journal Article

In: Blood, 120 (5), pp. 1005–1014, 2012.



Cassani, B; Poliani, P L; Moratto, D; Sobacchi, C; Marrella, V; Imperatori, L; Vairo, D; Plebani, A; Giliani, S; Vezzoni, P; Facchetti, F; Porta, F; Notarangelo, L D; Villa, A; Badolato, R

Đefect of regulatory Ŧ cells in patients with Omenn syndrome Journal Article

In: J Allergy Clin Immunol, 125 (1), pp. 209–216, 2010.



Marrella, V; Poliani, P L; Casati, A; Rucci, F; Frascoli, L; Gougeon, M L; Lemercier, B; Bosticardo, M; Ravanini, M; Battaglia, M; Roncarolo, M G; Cavazzana-Calvo, M; Facchetti, F; Notarangelo, L D; Vezzoni, P; Grassi, F; Villa, A

A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome Journal Article

In: J Clin Invest, 117 (5), pp. 1260–1269, 2007.



Storini, C; Rossi, E; Marrella, V; Distaso, M; Veerhuis, R; Vergani, C; Bergamaschini, L; Simoni, M G De

C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation Journal Article

In: Neurobiol Dis, 19 (1-2), pp. 10–17, 2005.