Barbara Cassani

@article{pmid32311393,

title = {Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome},

author = {R Rigoni and E Fontana and K Dobbs and V Marrella and V Taverniti and V Maina and A Facoetti and G DÁmico and W Al-Herz and M E Cruz-Munoz and C Schuetz and A R Gennery and E K Garabedian and S Giliani and D Draper and G Dbaibo and R S Geha and I Meyts and T Tousseyn and B Neven and D Moshous and A Fischer and A Schulz and A Finocchi and D B Kuhns and D L Fink and M S Lionakis and M Swamydas and S Guglielmetti and J Alejo and I A Myles and S Pittaluga and L D Notarangelo and A Villa and B Cassani},

year  = {2020},

date = {2020-11-01},

journal = {J Allergy Clin Immunol},

volume = {146},

number = {5},

pages = {1165--1179},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31295380,

title = {Absence of Đipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss},

author = {C Menale and L J Robinson and E Palagano and R Rigoni and M Erreni and A J Almarza and D Strina and S Mantero and M Lizier and A Forlino and R Besio and M Monari and P Vezzoni and B Cassani and H C Blair and A Villa and C Sobacchi},

year  = {2019},

date = {2019-01-01},

journal = {J Bone Miner Res},

volume = {34},

number = {11},

pages = {2133--2148},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid29105104,

title = {B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury},

author = {F Faggioli and E Palagano and L Di Tommaso and M Donadon and V Marrella and C Recordati and S Mantero and A Villa and P Vezzoni and B Cassani},

year  = {2018},

date = {2018-01-01},

journal = {Hepatology},

volume = {67},

number = {5},

pages = {1970--1985},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{rigoni_intestinal_2016,

title = {Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects},

author = {Rosita Rigoni and Elena Fontana and Simone Guglielmetti and Bruno Fosso and Anna Maria D'Erchia and Virginia Maina and Valentina Taverniti and Maria Carmina Castiello and Stefano Mantero and Giovanni Pacchiana and Silvia Musio and Rosetta Pedotti and Carlo Selmi and Rodrigo J Mora and Graziano Pesole and Paolo Vezzoni and Pietro Luigi Poliani and Fabio Grassi and Anna Villa and Barbara Cassani},

doi = {10.1084/jem.20151116},

issn = {1540-9538},

year  = {2016},

date = {2016-03-01},

journal = {The Journal of Experimental Medicine},

volume = {213},

number = {3},

pages = {355--375},

abstract = {Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated. Here, we show that Rag2(R229Q) knock-in mice developed an inflammatory bowel disease affecting both the small bowel and colon. Lymphocytes were sufficient for disease induction, as intestinal CD4 T cells with a Th1/Th17 phenotype reproduced the pathological picture when transplanted into immunocompromised hosts. Moreover, oral tolerance was impaired in Rag2(R229Q) mice, and transfer of wild-type (WT) regulatory T cells ameliorated bowel inflammation. Mucosal immunoglobulin A (IgA) deficiency in the gut resulted in enhanced absorption of microbial products and altered composition of commensal communities. The Rag2(R229Q) microbiota further contributed to the immunopathology because its transplant into WT recipients promoted Th1/Th17 immune response. Consistently, long-term dosing of broad-spectrum antibiotics (ABXs) in Rag2(R229Q) mice ameliorated intestinal and systemic autoimmunity by diminishing the frequency of mucosal and circulating gut-tropic CCR9(+) Th1 and Th17 T cells. Remarkably, serum hyper-IgE, a hallmark of the disease, was also normalized by ABX treatment. These results indicate that intestinal microbes may play a critical role in the distinctive immune dysregulation of OS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid21925467,

title = {Gut-tropic Ŧ cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice},

author = {B Cassani and E J Villablanca and F J Quintana and P E Love and A Lacy-Hulbert and W S Blaner and T Sparwasser and S B Snapper and H L Weiner and J R Mora},

year  = {2011},

date = {2011-12-01},

journal = {Gastroenterology},

volume = {141},

number = {6},

pages = {2109--2118},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid20547828,

title = {Ħomeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome},

author = {B Cassani and P L Poliani and V Marrella and F Schena and A V Sauer and M Ravanini and D Strina and C E Busse and S Regenass and H Wardemann and A Martini and F Facchetti and M van der Burg and A G Rolink and P Vezzoni and F Grassi and E Traggiai and A Villa},

year  = {2010},

date = {2010-07-01},

journal = {J Exp Med},

volume = {207},

number = {7},

pages = {1525--1540},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid20109747,

title = {Đefect of regulatory Ŧ cells in patients with Omenn syndrome},

author = {B Cassani and P L Poliani and D Moratto and C Sobacchi and V Marrella and L Imperatori and D Vairo and A Plebani and S Giliani and P Vezzoni and F Facchetti and F Porta and L D Notarangelo and A Villa and R Badolato},

year  = {2010},

date = {2010-01-01},

journal = {J Allergy Clin Immunol},

volume = {125},

number = {1},

pages = {209--216},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid19652199,

title = {Integration of retroviral vectors induces minor changes in the transcriptional activity of Ŧ cells from AĐA-SCIĐ patients treated with gene therapy},

author = {B Cassani and E Montini and G Maruggi and A Ambrosi and M Mirolo and S Selleri and E Biral and I Frugnoli and V Hernandez-Trujillo and C Di Serio and M G Roncarolo and L Naldini and F Mavilio and A Aiuti},

year  = {2009},

date = {2009-01-01},

journal = {Blood},

volume = {114},

number = {17},

pages = {3546--3556},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid19179314,

title = {Gene therapy for immunodeficiency due to adenosine deaminase deficiency},

year  = {2009},

date = {2009-01-01},

journal = {N Engl J Med},

volume = {360", 

 Number="5},

pages = {447--458},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid18606301,

title = {Ħuman osteoclast-poor osteopetrosis with hypogammaglobulinemia due to ŦNFRSF11A (RANK) mutations},

author = {M M Guerrini and C Sobacchi and B Cassani and M Abinun and S S Kilic and A Pangrazio and D Moratto and E Mazzolari and J Clayton-Smith and P Orchard and F P Coxon and M H Helfrich and J C Crockett and D Mellis and A Vellodi and I Tezcan and L D Notarangelo and M J Rogers and P Vezzoni and A Villa and A Frattini},

year  = {2008},

date = {2008-07-01},

volume = {83},

number = {1},

pages = {64--76},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid18218852,

title = {Altered intracellular and extracellular signaling leads to impaired Ŧ-cell functions in AĐA-SCIĐ patients},

author = {B Cassani and M Mirolo and F Cattaneo and U Benninghoff and M Hershfield and F Carlucci and A Tabucchi and C Bordignon and M G Roncarolo and A Aiuti},

year  = {2008},

date = {2008-01-01},

journal = {Blood},

volume = {111},

number = {8},

pages = {4209--4219},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid17671653,

title = {Multilineage hematopoietic reconstitution without clonal selection in AĐA-SCIĐ patients treated with stem cell gene therapy},

year  = {2007},

date = {2007-01-01},

journal = {J Clin Invest},

volume = {117},

number = {8},

pages = {2233--2240},

keywords = {},

pubstate = {published},

tppubtype = {article}

}