Genetic-Driven Druggable Target Identification and Validation
Matteo Floris, Stefania Olla, David Schlessinger and Francesco Cucca
Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant ﬁndings of coinci-dent associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here, we discuss opportunities and challenges, and infer criteria for the optimal use of genetic ﬁndings in the drug discovery pipeline.