Antonella Manca


Area of interest:

Dr Antonella Manca graduated in Biological Science at the University of Rome “La Sapienza” in 1988; after a PostDoc period in Netherland and Germany, where she was involved in the Human Genome Mapping Project particularly in Xq28 region mapping studies, she started working at the CNR in 1994. 

Her research activity focuses mainly on oncology studies, specifically on identification and characterization of molecular genetic alterations in candidate genes involved in solid tumor pathogenesis with particular focus on Malignant Melanoma. She’s also involved in molecular diagnostic of Glioblastoma for the purpose of addressing patients to personalized therapy.  

Expertise in sequencing and NGS analyses with multigene panel of tumor samples. 

Most significant publications:


Tramice, A; Paris, D; Manca, A; Agudelo, F A Guevara; Petrosino, S; Siracusa, L; Carbone, M; Melck, D; Raymond, F; Piscitelli, F

Analysis of the oral microbiome during hormonal cycle and its alterations in menopausal women: the Journal Article

In: Sci Rep, 12 (1), pp. 22086, 2022, ISSN: 2045-2322.

Abstract | Links | BibTeX

Andrea, Anichini; Alessandra, Molla; Gabriella, Nicolini; Eleonora, Perotti Valentina; Francesco, Sgambelluri; Alessia, Covre; Carolina, Fazio; Fortunata, Lofiego Maria; Maria, Di Giacomo Anna; Sandra, Coral; Antonella, Manca; Cristina, Sini Maria; Marina, Pisano; Teresa, Noviello; Francesca, Caruso; Silvia, Brich; Giancarlo, Pruneri; Andrea, Maurichi; Mario, Santinami; Michele, Ceccarelli; Giuseppe, Palmieri; Michele, Maio; Roberta, Mortarini

Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy Journal Article


Abstract | Links | BibTeX


Manca, Antonella; Sini, Maria Cristina; Cesinaro, Anna Maria; Portelli, Francesca; Urso, Carmelo; Lentini, Maria; Cardia, Roberta; Alos, Llucia; Cook, Martin; Simi, Sara; Paliogiannis, Panagiotis; Giorgi, Vincenzo De; Cossu, Antonio; Palmieri, Giuseppe; Massi, Daniela

NGS-Based Analysis of Atypical Deep Penetrating Nevi Journal Article

In: Cancers (Basel), 13 (12), 2021, ISSN: 2072-6694.

Abstract | Links | BibTeX


Manca, A.; Paliogiannis, P.; Colombino, M.; Casula, M.; Lissia, A.; Botti, G.; Carac?, C.; Ascierto, P. A.; Sini, M. C.; Palomba, G.; Pisano, M.; Doneddu, V.; Cossu, A.; Palmieri, G.; Dedola, M. F.; Fedeli, M. A.; Montesu, M. A.; Rubino, C.; Satta, R.; Scotto, T.; Sini, G.; Maio, M.; Massi, D.; Anichini, A.; Pfeffer, U.; Ghiorzo, P.; Queirolo, P.; Quaglino, P.; Sileni, V. C.; Di Giacomo, A. M.

Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach Journal Article

In: J Transl Med, 17 (1), pp. 289, 2019.

Abstract | BibTeX


Palmieri, G.; Colombino, M.; Casula, M.; Manca, A.; Mandal?, M.; Cossu, A.

Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches Journal Article

In: Curr Oncol Rep, 20 (11), pp. 86, 2018.

Abstract | BibTeX


Palmieri, G.; Ombra, M.; Colombino, M.; Casula, M.; Sini, M.; Manca, A.; Paliogiannis, P.; Ascierto, P. A.; Cossu, A.

Multiple Molecular Pathways in Melanomagenesis: Characterization of Ŧherapeutic Ŧargets Journal Article

In: Front Oncol, 5 , pp. 183, 2015.

Abstract | BibTeX


Colombino, M.; Capone, M.; Lissia, A.; Cossu, A.; Rubino, C.; De Giorgi, V.; Massi, D.; Fonsatti, E.; Staibano, S.; Nappi, O.; Pagani, E.; Casula, M.; Manca, A.; Sini, M.; Franco, R.; Botti, G.; Carac?, C.; Mozzillo, N.; Ascierto, P. A.; Palmieri, G.

BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma Journal Article

In: J Clin Oncol, 30 (20), pp. 2522–2529, 2012.

Abstract | BibTeX


Manca, A.; Sini, M. C.; Izzo, F.; Ascierto, P. A.; Tatangelo, F.; Botti, G.; Gentilcore, G.; Capone, M.; Mozzillo, N.; Rozzo, C.; Cossu, A.; Tanda, F.; Palmieri, G.

Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (AĐI) in melanoma cells Journal Article

In: 25 (6), pp. 1495–1502, 2011.

Abstract | BibTeX