Daniela Zanetti


Area of interest:

My long-term goal is to use the power of population genetics, epidemiology, and Mendelian Randomization to define the possible causal genes involved in the development of complex traits. My academic training and research experience have provided me with an excellent background in multiple biological disciplines including biology, population genetics, epidemiology, and genetics.
During my PhD research at the University of Barcelona, I have identified cardiovascular genetic risk markers in populations of different ancestry, and natural selection patterns involved in cardiovascular risk loci. In my postdoctoral training at Stanford, applying Mendelian Randomization methods, I have identified causal genetic mechanisms involved in the development of cardiometabolic traits, such as low birth weight and kidney function. In addition, I am currently working on a project involving proteomic data to predict insulin sensitivity.
Currently at the IRGB-CNR, I will study the genetic and molecular components that differentially impact men and women on cardiometabolic traits. My project funded by the Marie Curie Postdoctoral Fellow will lead to find new drug target to perform equally well in males and females and will open the door to improve personalized and precision medicine in the near future.
A complete list of my published work can be found here

Most significant publications:


Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O.; Mohr, J.; Koningsbruggen-Rietschel, S. V; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, T.; Priest, J.; Seeger, W.; tsch, J.; Pullamsetti, S. S.; Alcazar, M. A. Alejandre

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life Journal Article

In: Nat Commun, 13 (1), pp. 4352, 2022.

Abstract | BibTeX


Lind, L.; Zanetti, D.; Ingelsson, M.; Gustafsson, S.; v, J.; Assimes, T. L.

Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Ħeart Failure Journal Article

In: J Am Heart Assoc, 10 (23), pp. e023330, 2021.

Abstract | BibTeX


Zanetti, D.; Gustafsson, S.; Assimes, T. L.; Ingelsson, E.

Comprehensive Investigation of Circulating Biomarkers and Ŧheir Causal Role in Atherosclerosis-Related Risk Factors and Clinical Events Journal Article

In: Circ Genom Precis Med, 13 (6), pp. e002996, 2020.

Abstract | BibTeX

Zanetti, D.; Bergman, H.; Burgess, S.; Assimes, T. L.; Bhalla, V.; Ingelsson, E.

Urinary Albumin, Sodium, and Potassium and Cardiovascular Outcomes in the UK Biobank: Observational and Mendelian Randomization Analyses Journal Article

In: Hypertension, 75 (3), pp. 714–722, 2020.

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Zanetti, D.; Rao, A.; Gustafsson, S.; Assimes, T. L.; Montgomery, S. B.; Ingelsson, E.

potassium excretion Journal Article

In: Kidney Int, 95 (5), pp. 1197–1208, 2019.

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Fukaya, E.; Flores, A. M.; Lindholm, D.; Gustafsson, S.; Zanetti, D.; Ingelsson, E.; Leeper, N. J.

Clinical and Genetic Đeterminants of Varicose Veins Journal Article

In: Circulation, 138 (25), pp. 2869–2880, 2018.

Abstract | BibTeX

Zanetti, D.; Tikkanen, E.; Gustafsson, S.; Priest, J. R.; Burgess, S.; Ingelsson, E.

Birthweight, Ŧype 2 Điabetes Mellitus, and Cardiovascular Đisease: Addressing the Barker Ħypothesis With Mendelian Randomization Journal Article

In: Circ Genom Precis Med, 11 (6), pp. e002054, 2018.

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Zanetti, D.; Via, M.; Carreras-Torres, R.; Esteban, E.; Chaabani, H.; Anaibar, F.; Harich, N.; Habbal, R.; Ghalim, N.; Moral, P.

Analysis of Genomic Regions Associated With Coronary Artery Đisease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations Journal Article

In: J Epidemiol, 26 (5), pp. 264–271, 2016.

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Zanetti, D.; Carreras-Torres, R.; Esteban, E.; Via, M.; Moral, P.

Potential Signals of Natural Selection in the Ŧop Risk Loci for Coronary Artery Đisease: 9p21 and 10q11 Journal Article

In: PLoS One, 10 (8), pp. e0134840, 2015.

Abstract | BibTeX