Finding longevity genes is only one of many goals for gerontologists. An equally important mission is unravelling the genetic processes involved in age-related traits and diseases. IRGB and NIA are focusing their attention on the Mediterranean island of Sardinia. Why? We quote directly from the rationale and background for the initiation of the study in 2001, which also apply to follow-up studies in the course of the Project.
The Sardinian Transcriptome Project The interpretation of GWAS is extremely challenging since most candidate loci fall in non-coding regions and are difficult to interpret. Given the important role of regulatory variation in shaping phenotypic complexity, expression Quantitative Trait Loci (eQTLs) have been proposed as informative intermediate phenotypes between genomic sequence variation and human [...]
The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence. This is being accomplished by genome wide association studies using ultra-high definition polychromatic flow cytometry of circulating cells The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence.
The Sardinian Genome Project for medical and human evolution discovery Next generation sequencing has revolutionized the resolution of genetic analyses. Since 2010, the IRGB institute has exploited this advanced technology with a lowpass sequencing approach aiming at the genetic characterization of the Sardinian population. We sequenced about 3,500 whole genomes discovering more [...]
The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence. This is being accomplished by genome wide association studies using ultra-high definition polychromatic flow cytometry of circulating cells The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence.