Stefania Olla

Researcher

Area of interest:

A computational chemist, with organic synthesis background and ability to plan, coordinate projects and resources. In depth expertise in supporting drug discovery optimization programs via the development and application of virtual screening technologies such as structure-based and ligand-based pharmacophore models, docking calculations. In depth knowledge in 3D QSAR, homology modelling, ADME-Tox and virtual screening cascade. Identification and selection of in silico druggable target resulting from genetic associations. Identification and selection of druggable targets and development of target-based and phenotypic assays. Expertise in autoimmune diseases including multiple sclerosis and central nervous system diseases. In silico approaches have been applied to identify and optimize kinase inhibitors as potential anticancer agents, antifungal agents, sirtuin modulators and protein-protein inhibitors. Excellent ability to work as a team, organization, flexibility, punctuality and responsibility.

Most significant publications:

2024

Veroni, C.; Olla, S.; Brignone, M. S.; Siguri, C.; Formato, A.; Marra, M.; Manzoli, R.; Macario, M. C.; Ambrosini, E.; Moro, E.; Agresti, C.

The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation Journal Article

In: Biomolecules, 14 (4), 2024, ([PubMed Central:hrefhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948512PMC2948512] [DOI:hrefhttps://dx.doi.org/10.1371/journal.pone.001312810.1371/journal.pone.0013128] [PubMed:hrefhttps://www.ncbi.nlm.nih.gov/pubmed/2095704620957046]).

Abstract | BibTeX

2023

Olla, S.; Siguri, C.; Fais, A.; Era, B.; Fantini, M. C.; "Di Petrillo, A.

Inhibitory Effect of Quercetin on Oxidative Endogen Enzymes: A Focus on Putative Binding Modes Journal Article

In: Int J Mol Sci, 24 (20), 2023.

Abstract | BibTeX

Colombo, E.; Olla, S.; Minnelli, C.; Formato, A.; Veroni, C.; Corbisiero, S.; Pericolo, M.; Siguri, C.; Mobbili, G.; Agresti, C.; Seneci, P.

Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes Journal Article

In: 28 (19), 2023.

Abstract | BibTeX

2021

Olla, S.; Steri, M.; Formato, A.; Whalen, M. B.; Corbisiero, S.; Agresti, C.

Combining Human Genetics of Multiple Sclerosis with Oxidative Stress Phenotype for Đrug Repositioning Journal Article

In: Pharmaceutics, 13 (12), 2021.

Abstract | BibTeX

2020

Orrù, V; Steri, M; Sidore, C; Marongiu, M; Serra, V; Olla, S; Sole, G; Lai, S; Dei, M; Mulas, A; Virdis, F; Piras, MG; Lobina, M; Marongiu, M; Pitzalis, M; Deidda, F; Loizedda, A; Onano, S; Zoledziewska, M; Sawcer, S; Devoto, M; Gorospe, M; Abecasis, GR; Floris, M; Pala, M; Schlessinger, D; Fiorillo, E; Cucca, F

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy Journal Article

In: Nat Genet, 52 (10), pp. 1036–1045, 2020.

Abstract | BibTeX

2018

Floris, M; Olla, S; Schlessinger, D; Cucca, F

Genetic-Driven Druggable Target Identification and Validation Journal Article

In: Trends Genet., 34 (7), pp. 558–570, 2018.

Abstract | Links | BibTeX

2017

Steri, Maristella; Orrù, Valeria; Idda, Laura M; Pitzalis, Maristella; Pala, Mauro; Zara, Ilenia; Sidore, Carlo; Faà, Valeria; Floris, Matteo; Deiana, Manila; Asunis, Isadora; Porcu, Eleonora; Mulas, Antonella; Piras, Maria G; Lobina, Monia; Lai, Sandra; Marongiu, Mara; Serra, Valentina; Marongiu, Michele; Sole, Gabriella; Busonero, Fabio; Maschio, Andrea; Cusano, Roberto; Cuccuru, Gianmauro; Deidda, Francesca; Poddie, Fausto; Farina, Gabriele; Dei, Mariano; Virdis, Francesca; Olla, Stefania; Satta, Maria A; Pani, Mario; Delitala, Alessandro; Cocco, Eleonora; Frau, Jessica; Coghe, Giancarlo; Lorefice, Lorena; Fenu, Giuseppe; Ferrigno, Paola; Ban, Maria; Barizzone, Nadia; Leone, Maurizio; Guerini, Franca R; Piga, Matteo; Firinu, Davide; Kockum, Ingrid; Bomfim, Izaura Lima; Olsson, Tomas; Alfredsson, Lars; Suarez, Ana; Carreira, Patricia E; Castillo-Palma, Maria J; Marcus, Joseph H; Congia, Mauro; Angius, Andrea; Melis, Maurizio; Gonzalez, Antonio; Riquelme, Marta E Alarcón; da Silva, Berta M; Marchini, Maurizio; Danieli, Maria G; Giacco, Stefano Del; Mathieu, Alessandro; Pani, Antonello; Montgomery, Stephen B; Rosati, Giulio; Hillert, Jan; Sawcer, Stephen; D'Alfonso, Sandra; Todd, John A; Novembre, John; Abecasis, Gonçalo R; Whalen, Michael B; Marrosu, Maria G; Meloni, Alessandra; Sanna, Serena; Gorospe, Myriam; Schlessinger, David; Fiorillo, Edoardo; Zoledziewska, Magdalena; Cucca, Francesco

Overexpression of the Cytokine BAFF and Autoimmunity Risk Journal Article

In: The New England Journal of Medicine, 376 (17), pp. 1615–1626, 2017, ISSN: 1533-4406, (See Editorials, Korn T, Oukka M. A BAFFling Association between Malaria Resistance and the Risk of Multiple Sclerosis. N Engl J Med. 2017 Apr 27;376(17):1680-1681. doi: 10.1056/NEJMe1700720.; Stohl W., Systemic lupus erythematosus: BAFF emerges from the genetic shadows. Nat Rev Rheumatol. 2017 Jun 15. doi: 10.1038/nrrheum.2017.99; Comabella M. Neuroimmunology: B cells and variant BAFF in autoimmune disease. Nat Rev Neurol. 2017 Jun 16. doi: 10.1038/nrneurol.2017.87.).

Abstract | Links | BibTeX

Eleuteri, C.; Olla, S.; Veroni, C.; Umeton, R.; Mechelli, R.; Romano, S.; Buscarinu, M. C.; Ferrari, F.; Cal?, G.; Ristori, G.; Salvetti, M.; Agresti, C.

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials Journal Article

In: Sci Rep, 7 , pp. 45780, 2017.

Abstract | BibTeX

2009

Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors Journal Article

In: Bioorg Med Chem Lett, 19 (5), pp. 1512–1516, 2009.

Abstract | BibTeX