Search for genetic factors implicated in Hirschsprung Associated Enterocolitis Search for genetic factors implicated in Hirschsprung Associated Enterocolitis Hirschsprung's disease (HSCR) is a congenital gut malformation caused by a lack of innervation that affects about 1 in 5000 live births [1]. One of the most serious complications is constituted by enterocolitis [...]
(BRAVEinMS) Bioinformatics and cell ReprogrAmming to deVElop an IN vitro platform to discover new drugs for progressive Multiple Sclerosis (BRAVEinMS) BRAVEinMS rises from the joint efforts of laboratories from five different countries in Europe and North America with the aim of merging and synergizing unique competences in order to identifying promising molecules that can counteract the progression [...]
WOMEN4HEALTH A unique cohort to study mechanisms underlying cardiometabolic disorders in Women www.women4health.it Do you know that the leading cause of death for women is not breast or uterine cancer, but cardiometabolic diseases, which include type 2 diabetes and metabolic syndrome? Italian, national statistical data from 2018 indicates that the incidence [...]
PREDICT PREcision meDicine In ColorecTal cancer: new clinical-genomic network for expanding tailored oncologic care. The most prevalent approach of molecular oncology focuses on the analysis of the entire tumor mass and identifies profiles of the genetic variants of neoplasms arising from both healthy and neoplastic cells. Genomics, epigenomics [...]
"Triple Negative" breast cancer therapy Immunohistochemical panel and epigenetic markers for predictive purposes in "Triple Negative" breast cancer therapy. "Triple Negative" breast cancer (TNBC) is a morphologically and genetically heterogeneous tumor. It represents the rarest BC subtype (12-24%) but the aggressive clinical behavior and high histologic grade cause [...]
NEUDIG Unveiling the hidden side of NEUrodevelopmental DIsorder Genetics: a multidisciplinary pathway to new molecular diagnoses by integrating genomic, transcriptomic, and functional analyses. Neurodevelopmental disorders (NDDs) are a group of disorders caused by the disruption of essential neurodevelopmental processes. NDDs include autism spectrum disorder, intellectual disability, attention deficit hyperactivity [...]
AppliCare Antimicrobial peptides loaded inhalable calcium phosphates nanoparticles for the counteraction of antibiotic resistance: towards a new therapy for respiratory infections The aim of AppliCare is to develop a new therapeutic formulation based on inhalable and biodegradable calcium phosphate nanoparticles (NPs) functionalized with novel peptides (AMPs). Peptides (AMPs) will be identified [...]
(BRAVEinMS) Bioinformatics and cell ReprogrAmming to deVElop an IN vitro platform to discover new drugs for progressive Multiple Sclerosis (BRAVEinMS) BRAVEinMS rises from the joint efforts of laboratories from five different countries in Europe and North America with the aim of merging and synergizing unique competences in order to identifying promising molecules that can counteract the progression [...]
WOMEN4HEALTH A unique cohort to study mechanisms underlying cardiometabolic disorders in Women Do you know that the leading cause of death for women is not breast or uterine cancer, but cardiometabolic diseases, which include type 2 diabetes and metabolic syndrome? Italian, national statistical data from 2018 indicates that the incidence of [...]
We are studying the gut microbiome and human genome of about 8,000 from the Dutch Microbiome Project, an ambitious project involving volunteers of the Lifelines Population Biobank. In this project we aim to investigate if and how host genome affects microbiome composition and function.
Selection with a molecUlar PanEl foR Panitunumab Efficacy in K-ras and n-ras wild type metastatic colorectal cancer. This study aims to prospectively define a molecular panel able to identify patients more likely to benefit from the use of first-line panitumumab in combination with mFOLFOX.
Sequential Combo Immuno & Target therapy (SECOMBIT) study. A three arms prospective, randomized phase II study to evaluate the best sequential approach with combo immunotherapy (ipilimumab/ nivolumab) & combo target therapy (LGX818/MEK162) in patients with metastatic melanoma and BRAF mutation [...]