Project Description


Molecular circuits of sex dimorphism in cardiomethabolic traits and risk factors

Sex Dimorphism is the project 101066678 (

developed by Daniela Zanetti under the supervision of Serena Sanna at the Institute of Genetic and Biomedical Research (IRGB) of the National Research Council (CNR) of Cagliari.

This project aims to understand the genetic and molecular components that differentially impact men and women in cardiometabolic traits and risk factors. These conditions exhibit some degree of sex differences, including differences in incidence or prevalence, age of onset, severity, disease progression, and response to treatment and pharmacological adverse events. Unfortunately, the reasons behind this sex dimorphism are largely unknown.

The mechanistic findings of the project are going to be highly relevant, especially for clinical and pharmaceutical sectors. These insights will accelerate the development of new sex-tailored prevention strategies, through potential sex specific druggable targets that may be pivotal for personalized and precision medicine.

Funding sources:

The project is funded by the MSCA Postdoctoral Fellowships 2021.

Research Team:

The project is led by Daniela Zanetti, researcher at the IRGB-CNR, and supervised by Serena Sanna, head of research at the IRGB-CNR.


Several collaborators from the University of Stanford (California) and from the University of Groningen (NL) will be involved in the project.

Relevant links: