Understanding Prostate Cancer Investigation of prostate cancer heterogeneity as a key to dissecting its characteristic cell subtypes Prostate cancer (PC) is the most frequently diagnosed malignancy among men, accounting for approximately 19% of all male cancers, and remains clinically challenging due to its often-indolent nature and unpredictable prognosis. Despite widespread use [...]
INFERTILITY Definition of a personalized signature of chronic inflammation and early aging predictive of the development of comorbidities in infertile men. Infertility is a disease of near-endemic prevalence, affecting up to 15% of couples of reproductive age. A pure male factor accounts for at least 30% of infertility cases. Emerging clinical [...]
CROME Colorectal cancer Research via Omics integration: Microbiome, miRNA, and Expression profiling This project proposes a multidimensional and integrative approach for the comprehensive molecular characterization of Colorectal cancer (CRC) through the combined use of next-generation technologies. These include single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, gut microbiome profiling, microRNA (miRNA) analysis, and [...]
PRIN 2022 Harnessing the genetics of gastrointestinal endophenotypes as a strategy to improve prevention, treatment and therapeutic precision in irritable bowel syndrome (IBS) IBS (Irritable Bowel Syndrome) affects 10-15% of the population, causing recurrent abdominal pain, bloating, constipation, and diarrhea. These symptoms can worsen due to stress, diet, or hormonal changes. The [...]
In search of novel bioactive compounds as potential anticancer agents: Iodinated 4,4’-Bipyridines A proof-of-principle exploration aiming to investigate the effectiveness of new iodinated compounds against melanoma cells In the last decade, biological processes involving halogen bond (HaB) as a leading interaction attracted great interest. Iodinated 4,4’-bipyridines showed interesting properties as HaB [...]
T-WIN - Clinical Trial Pattern of response/progression to first line treatment with Dabrafenib and Trametenib in patients with Unresectable or Metastatic BRAF Mutation–Positive Cutaneous Melanoma Prospective observational study involving up to 200 patients from 25 health units: Patients with histologically confirmed cutaneous melanoma that is either stage IIIC or stage IV, and [...]
Homologous Recombination Ovarian Cancer Identification of new prognostic and predictive markers of therapeutic response in patients with advanced ovarian cancer by identifying alterations in homologous recombination (HRD) in the Sardinian population. The study is conducted on a cohort of patient from the female population of North Sardinia. Aim of the [...]
SEX DIMORPHISM Molecular circuits of sex dimorphism in cardiomethabolic traits and risk factors Sex Dimorphism is the project 101066678 (https://cordis.europa.eu/project/id/101066678) developed by Daniela Zanetti under the supervision of Serena Sanna at the Institute of Genetic and Biomedical Research (IRGB) of the National Research Council (CNR) of Cagliari. This project aims to [...]
SEMICYCLE Deciphering female’s SEx hormones - MIcrobiota interactions during a menstrual CYCLE for an efficient personalized medicine in cardiometabolic disorders The project “SEMICYCLE” aims at understanding the interactions between females’ sex hormones and the microbiota for an efficient personalized medicine in cardiometabolic disorders in women: in particular, it responds to the [...]
(AGE-it) Aging well in an ageing society AGE-IT is a network of Universities, research institutions and companies that brings together skills for the development of 10 different areas. A total of 27 subjects participate in the Age-it Extended Partnership. The partnership includes the University of Florence, the University of Milan Bicocca, [...]
AD MAIORA A multi-Dimensional Model of cAre and transItion for patients with cOmplex RAre diseases: challenges in the era of new technologies Over the past century, the progress in biomedical sciences gave outstanding contributions to the understanding of human conditions, and even curing some of them. Recent advances in high-throughput technologies [...]
DETECT DEciphering geneTic hEterogeneity in ColorecTal cancer: in situ and circulating cell subtypes identification Colorectal cancer (CRC) is the 2nd most mortal cancer worldwide, despite advances in healthcare and screening, CRC remains a major public health problem. Tumor drug resistance dues to inter and intratumor heterogeneity (ITH) is the mainly cause [...]